VATICAN CITY - Roman Catholic leaders from around the world made an unprecedented joint appeal on Monday to a forthcoming U.N. conference on climate change to produce "a truly transformational" agreement to stem global warming.

The Catholic cardinals, patriarchs and bishops signed the appeal in the Vatican, saying climate change had to address social justice and that any agreement must be fair and ensure the poor and most vulnerable were not sold short.

Their 10-point document was based on Pope Francis's landmark encyclical last June, called "Laudato Si", which demanded urgent action to save the planet from environmental ruin.

It again put the 1.2 billion-member Catholic Church in the front line of the debate over the causes of climate change, an active role that some Catholic conservatives, including U.S. Republican presidential candidate Jeb Bush, have criticized.

The document said "reliable scientific evidence" suggests global warming is the result of "unrestrained human activity", current models of progress and development, and excessive reliance on fossil fuels. Climate change skeptics argue that man's role in global warming has not been conclusively proved.

"The pope and Catholic Bishops from five continents, sensitive to the damage caused, appeal for a drastic reduction in the emission of carbon dioxide and other toxic gases," said the appeal to the conference, which meets in Paris from Nov. 30 to Dec. 11.(Reuters)